ECG database labeled with subcellular pathologies developed by multi-scale heart simulator, UT-Heart


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We have developed a multi-scale multi-physics heart simulator 'UT-Heart', in which more than 20,000,000 cell models of cardiac electrophysiology are implemented while reproducing the microscopic tissue structure in a realistic 3D heart model. As for the cell model, we implemented the human ventricular myocyte model by O’Hara et al. with some modifications. The details of the model can be seen in the literature listed below. Using this heart model, we created an ECG dataset by repeating the beating heart simulations while varying the activities of functional molecules, tissue structure, morphology and the loading condition of the heart under normal and failing conditions as reported in the literatures. File name of each 12 lead ECG data was formatted to indicate how each simulation parameter was modified (please see the following example).

Example of filename:ECG.G1INa0ICa1NCX1IK2LV1EX0CELL0HR0CIR0.out

INa*: Conductance of sodium current (INa, INaL) was set at (0) normal or (1) 70% of normal
G*: Conduction velocity in fiber/cross-fiber directions in either 100%/100% of normal (0), 80%/120% (1) or 80%/100% (2).
ICa*: Parameters of calcium handling proteins including L-type calcium current (ICa,L), sarcoplasmic reticulum (SR) Ca pump (SERCA) and SR calcium release channel (CaRC) were set at normal (0) or 70%/50%/150% (1).
NCX*: The activity of sodium-calcium exchanger current (NCX) was set at normal (0) or 150% of normal (1).
IK* : Conductances of potassium current including IKs, IKr, Ito and IK1 were set at either normal (0), 50%/80%/80%/80% of normal (1), or 30%/50%/30%/50% of normal (2).
LV*: The sphericity of LV quantified by the sphericity index (SI=long axis length/diameter) was set at 0.53 (0) or 0.68 (1).
EX*: Ventricular activation pattern was modified as normal (0), left axis deviation (1), right axis deviation (2) and a mild delay in right ventricular activation (3).
CELL*: We arranged the three-type of ventricular cell models, i.e., endocardial cell, M-cell, and epicardial cell, in five ways. From endocardial side to epicardial side, cells were distributed in the following manner (in volume ratio). 20%/45%/35% (0), 0%/0%/100% (1), 65%/0%/35% (2), 25%/30%/45% (3), 100%/0%/0% (4).

Each file contains digitized ECG data sampled at 500 Hz, with 12 lead of data in column wise. Numeric data can be converted to mV by multiplying 0.00488.

References
1. O’Hara T, Virag L, Varro A, Rudy Y (2011). Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation. PLoS Comput Biol 7:e1002061.
2. Okada J, Yoshinaga T, Kurokawa J, Washio T, Furukawa T, Sawada K, Sugiura S, Hisada T Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator Science Advances (2015) 01 May 2015: e1400142
3. Okada J, Yoshinaga T, Kurokawa J, Washio T, Furukawa T, Sawada K, Sugiura S, Hisada T Arrhythmic hazard map for a 3D whole-ventircles model under multiple ion channel block Brit J Pharmacol https://doi.org/10.1111/bph.14357 (2018)
4. Sugiura, S., Okada, JI., Washio, T., Hisada, T. (2022). UT-Heart: A Finite Element Model Designed for the Multiscale and Multiphysics Integration of our Knowledge on the Human Heart. In: Cortassa, S., Aon, M.A. (eds) Computational Systems Biology in Medicine and Biotechnology. Methods in Molecular Biology, vol 2399. Humana, New York, NY.

This work was supported by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) under the “Program for Promoting Research on the Supercomputer Fugaku” (hp210180).

Contact E-mail : contact[at]ut-heart.com



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