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Selected Papers

  1. Washio T, Fujii A, Hisada T. On random force correction for large time steps in semi-implicitly discretized overdamped Langevin equations. AIMS Mathematics 2024, 9(8); 20793-20810.
  2. Okada J, Washio T, Sugiura S, Hisada T. Transition mechanisms from atrial flutter to atrial fibrillation during anti-tachycardia pacing therapy. Pacing and Clinical Electrophysiology. 2023;46(12):1509-18.
  3. Okada J, Washio T, Sugiura S, Hisada T. Low-energy defibrillation using a base–apex epicardial electrode. Pacing and Clinical Electrophysiology. 2023;46(11):1325-32.
  4. Yoneda K, Kanada R, Okada J, Watanabe M, Sugiura S, Hisada T, Washio T. A thermodynamically consistent monte carlo cross-bridge model with a trapping mechanism reveals the role of stretch activation in heart pumping. Front Physiol. 2022;13(855303).
  5. Washio T, Cui X, Kanada R, Okada J, Sugiura S, Okuno Y, Takada S, Hisada T, Using incomplete Cholesky factorization to increase the time step in molecular dynamics simulations, Journal of Computational and Applied Mathematics. 2022; 415:114519.
  6. Washio T, Kanada R, Cui X, Okada J, Sugiura S, Takada S, Hisada T. Semi-Implicit Time Integration with Hessian Eigenvalue Corrections for a Larger Time Step in Molecular Dynamics Simulations. Journal of Chemical Theory and Computation. 2021;17(9):5792-804.
  7. Hwang Y, Washio T, Hisada T, Higuchi H, Kaya M. A reverse stroke characterizes the force generation of cardiac myofilaments, leading to an understanding of heart function. Proceedings of the National Academy of Sciences. 2021;118(23):e2011659118.
  8. Yoneda K, Okada J, Watanabe M, Sugiura S, Hisada T, Washio T. A Multiple Step Active Stiffness Integration Scheme to Couple a Stochastic Cross-Bridge Model and Continuum Mechanics for Uses in Both Basic Research and Clinical Applications of Heart Simulation. Frontiers in Physiology. 2021;12(1179).
  9. Masuda H, Miyagawa S, Sugiura S, Washio T, Okada J, Ueno T, Toda K, Kuratani T, Hisada T, Sawa Y. An application of a patient-specific cardiac simulator for the prediction of outcomes after mitral valve replacement: a pilot study. Journal of Artificial Organs. 2021;24(3):351-7.
  10. Okada J, Yoshinaga T, Washio T, Sawada K, Sugiura S, Hisada T. Chloroquine and hydroxychloroquine provoke arrhythmias at concentrations higher than those clinically used to treat COVID-19: A simulation study. Clinical and Translational Science. 2021;14(3):1092-100.
  11. Shintani SA, Washio T, Higuchi H. Mechanism of contraction rhythm homeostasis for hyperthermal sarcomeric oscillations of neonatal cardiomyocytes. Scientific Reports. 2020;10(1):20468.
  12. Okada J, Fujiu K, Yoneda K, Iwamura T, Washio T, Komuro I, Hisada T, Sugiura S. Ionic mechanisms of ST segment elevation in electrocardiogram during acute myocardial infarction. The Journal of Physiological Sciences. 2020;70(1):36.
  13. Washio T, Sugiura S, Okada J, Hisada T. Using Systolic Local Mechanical Load to Predict Fiber Orientation in Ventricles. Frontiers in Physiology. 2020;11(467). DOI:10.3389/fphys.2020.00467
  14. Isotani A, Yoneda K, Iwamura T, Watanabe M, Okada J, Washio T, Sugiura S, Hisada T, Ando K. Patient-specific heart simulation can identify non-responders to cardiac resynchronization therapy. Heart and Vessels. 2020. DOI:10.1007/s00380-020-01577-1
  15. Kariya T, Washio T, Okada J, Nakagawa M, Watanabe M, Kadooka Y, Sano S, Nagai R, Sugiura S, Hisada T. Personalized Perioperative Multi-scale, Multi-physics Heart Simulation of Double Outlet Right Ventricle. Annals of Biomedical Engineering. 2020. DOI:10.1007/s10439-020-02488-y
  16. Okada J, Fujiu K, Washio T, Sugiura S, Hisada T, Hasumi E, Komuro I. Longitudinal dissociation and transition in thickness of the His-Purkinje system cause various QRS waveforms of surface ECG under His bundle pacing: A simulation study based on clinical observations. Journal of Cardiovascular Electrophysiology. 2019;30(11):2582-90.
  17. Okada J, Washio T, Sugiura S, Hisada T. Clinical and pharmacological application of multiscale multiphysics heart simulator, UT-Heart. Korean J Physiol Pharmacol. 2019;23(5):295-303.
  18. Washio T, Shintani SA, Higuchi H, Sugiura S, Hisada T. Effect of myofibril passive elastic properties on the mechanical communication between motor proteins on adjacent sarcomeres. Scientific Reports. 2019;9(1):9355.
  19. Okada J, Yoshinaga T, Kurokawa J, Washio T, Furukawa T, Sawada K, Sugiura S, Hisada T. Arrhythmic hazard map for a 3D whole-ventricle model under multiple ion channel block. British Journal of Pharmacology. 2018;175(17):3435-52.
  20. Washio T, Sugiura S, Kanada R, Okada J, Hisada T. Coupling Langevin Dynamics With Continuum Mechanics: Exposing the Role of Sarcomere Stretch Activation Mechanisms to Cardiac Function. Frontiers in Physiology. 2018;9(333).
  21. Okada J, Washio T, Nakagawa M, Watanabe M, Kadooka Y, Kariya T, Yamashita H, Yamada Y, Momomura S, Nagai R, Hisada T, Sugiura S. Absence of Rapid Propagation through the Purkinje Network as a Potential Cause of Line Block in the Human Heart with Left Bundle Branch Block. Frontiers in Physiology. 2018;9(56).
  22. Washio T, Hisada T, Shintani SA, Higuchi H. Analysis of spontaneous oscillations for a three-state power-stroke model. Physical Review E. 2017;95(2):022411.
  23. Okada J, Washio T, Nakagawa M, Watanabe M, Kadooka Y, Kariya T, Yamashita H, Yamada Y, Momomura S, Nagai R, Hisada T, Sugiura S. Multi-scale, tailor-made heart simulation can predict the effect of cardiac resynchronization therapy. Journal of Molecular and Cellular Cardiology. 2017;108:17-23.
  24. Marcucci L, Washio T, Yanagida T. Titin-mediated thick filament activation, through a mechanosensing mechanism, introduces sarcomere-length dependencies in mathematical models of rat trabecula and whole ventricle. Scientific Reports. 2017;7:5546.
  25. Kaya M, Tani Y, Washio T, Hisada T, Higuchi H. Coordinated force generation of skeletal myosins in myofilaments through motor coupling. Nature Communications. 2017;8:16036.
  26. Imaizumi Y, Goda T, Schaffhauser DF, Okada J, Matsumoto A, Miyahara Y. Proton-sensing transistor systems for detecting ion leakage from plasma membranes under chemical stimuli. Acta Biomaterialia. 2017;50:502-9.
  27. Cui X, Washio T, Chono T, Baba H, Okada J, Sugiura S, Hisada T. Deformable regions of interest with multiple points for tissue tracking in echocardiography. Medical Image Analysis. 2017;35:554-69.
  28. Zhang G, Chen X, Ohgi J, Miura T, Nakamoto A, Matsumura C, Sugiura S, Hisada T. Biomechanical simulation of thorax deformation using finite element approach. BioMedical Engineering OnLine. 2016;15(1):18.
  29. Panthee N, Okada J, Washio T, Mochizuki Y, Suzuki R, Koyama H, Ono M, Hisada T, Sugiura S. Tailor-made heart simulation predicts the effect of cardiac resynchronization therapy in a canine model of heart failure. Medical Image Analysis. 2016;31:46-62.
  30. Marcucci L, Washio T, Yanagida T. Including Thermal Fluctuations in Actomyosin Stable States Increases the Predicted Force per Motor and Macroscopic Efficiency in Muscle Modelling. PLOS Computational Biology. 2016;12(9):e1005083.
  31. Mochizuki Y, Suzuki R, Teshima T, Matsumoto H, Panthee N, Sugiura S, Hisada T, Koyama H. Usefulness of dyssynchrony indices based on two-dimensional speckle tracking echocardiography in a canine model of left bundle branch block. Journal of Veterinary Cardiology. 2016;18(4):358-66.
  32. Washio T, Yoneda K, Okada J, Kariya T, Sugiura S, Hisada T. Ventricular fiber optimization utilizing the branching structure. International Journal for Numerical Methods in Biomedical Engineering. 2016;32(7):e02753.
  33. Yasuda C, Yasuda S, Yamashita H, Okada J, Hisada T, Sugiura S. The Human ETHER-A-GO-GO-Related Gene (hERG) Current Inhibition Selectively Prolongs Action Potential of Midmyocardial Cells to Augment Transmural Dispersion. JPP. 2015(4):13.
  34. Sugi H, Chaen S, Akimoto T, Minoda H, Miyakawa T, Miyauchi Y, Tanokura M, Sugiura S. Electron microscopic recording of myosin head power stroke in hydrated myosin filaments. Scientific Reports. 2015;5:15700.
  35. Okada J, Yoshinaga T, Kurokawa J, Washio T, Furukawa T, Sawada K, Sugiura S, Hisada T. Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator. Science Advances. 2015;1(4).
  36. Hatano A, Okada J, Washio T, Hisada T, Sugiura S. An integrated finite element simulation of cardiomyocyte function based on triphasic theory. Frontiers in Physiology. 2015;6(287).
  37. Hatano A, Okada J, Washio T, Hisada T, Sugiura S. Distinct Functional Roles of Cardiac Mitochondrial Subpopulations Revealed by a 3D Simulation Model. Biophysical journal. 2015;108(11):2732-9.
  38. Sugi H, Chaen S, Kobayashi T, Abe T, Kimura K, Saeki Y, Ohnuki Y, Miyakawa T, Tanokura M, Sugiura S. Definite Differences between In Vitro Actin-Myosin Sliding and Muscle Contraction as Revealed Using Antibodies to Myosin Head. PLOS ONE. 2014;9(6):e93272.
  39. Seo K, Inagaki M, Hidaka I, Fukano H, Sugimachi M, Hisada T, Nishimura S, Sugiura S. Relevance of cardiomyocyte mechano-electric coupling to stretch-induced arrhythmias: Optical voltage/calcium measurement in mechanically stimulated cells, tissues and organs. Progress in Biophysics and Molecular Biology. 2014;115(2):129-39.
  40. Washio T, Okada J, Takahashi A, Yoneda K, Kadooka Y, Sugiura S, Hisada T. Multiscale Heart Simulation with Cooperative Stochastic Cross-Bridge Dynamics and Cellular Structures. Multiscale Modeling & Simulation. 2013;11(4):965-99.
  41. Okada J, Sugiura S, Hisada T. Modeling for cardiac excitation propagation based on the Nernst-Planck equation and homogenization. Phys Rev E Stat Nonlin Soft Matter Phys. 2013;87(6):062701.
  42. Okada J, Sasaki T, Washio T, Yamashita H, Kariya T, Imai Y, Nakagawa M, Kadooka Y, Nagai R, Hisada T, Sugiura S. Patient Specific Simulation of Body Surface ECG using the Finite Element Method. Pacing and Clinical Electrophysiology. 2013;36(3):309-21.
  43. Katayama S, Umetani N, Hisada T, Sugiura S. Bicuspid aortic valves undergo excessive strain during opening: A simulation study. The Journal of Thoracic and Cardiovascular Surgery. 2013;145(6):1570-6.
  44. Hatano A, Okada J, Washio T, Hisada T, Sugiura S. Mitochondrial Colocalization with Ca(2+) Release Sites is Crucial to Cardiac Metabolism. Biophysical Journal. 2013;104(2):496-504.
  45. Asayama M, Kurokawa J, Shirakawa K, Okuyama H, Kagawa T, Okada J, Sugiura S, Hisada T, Furukawa T. Effects of an hERG Activator, ICA-105574, on Electrophysiological Properties of Canine Hearts. Journal of Pharmacological Sciences. 2013;121(1):1-8.
  46. Washio T, Okada J, Sugiura S, Hisada T. Approximation for Cooperative Interactions of a Spatially-Detailed Cardiac Sarcomere Model. Cellular and Molecular Bioengineering. 2012;5(1):113-26.
  47. Sugiura S, Washio T, Hatano A, Okada J, Watanabe H, Hisada T. Multi-scale simulations of cardiac electrophysiology and mechanics using the University of Tokyo heart simulator. Progress in Biophysics and Molecular Biology. 2012;110(2-3):380-9.
  48. Hatano A, Okada J, Hisada T, Sugiura S. Critical role of cardiac t-tubule system for the maintenance of contractile function revealed by a 3D integrated model of cardiomyocytes. Journal of Biomechanics. 2012;45(5):815-23.
  49. Okada J, Washio T, Maehara A, Momomura S, Sugiura S, Hisada T. Transmural and apicobasal gradients in repolarization contribute to T-wave genesis in human surface ECG. American Journal of Physiology - Heart and Circulatory Physiology. 2011;301(1):H200-H8.
  50. Hatano A, Okada J, Washio T, Hisada T, Sugiura S. A Three-Dimensional Simulation Model of Cardiomyocyte Integrating Excitation-Contraction Coupling and Metabolism. Biophysical Journal. 2011;101(11):2601-10.
  51. Washio T, Hisada T. Convergence analysis of inexact LU-type preconditioners for indefinite problems arising in incompressible continuum analysis. Japan Journal of Industrial and Applied Mathematics. 2011;28(1):89-117.
  52. Washio T, Okada J, Hisada T. A Parallel Multilevel Technique for Solving the Bidomain Equation on a Human Heart with Purkinje Fibers and a Torso Model. SIAM Review. 2010;52(4):717-43.
  53. Seo K, Inagaki M, Nishimura S, Hidaka I, Sugimachi M, Hisada T, Sugiura S. Structural Heterogeneity in the Ventricular Wall Plays a Significant Role in the Initiation of Stretch-Induced Arrhythmias in Perfused Rabbit Right Ventricular Tissues and Whole Heart Preparations. Circulation Research. 2010;106(1):176-84.
  54. Okada J, Washio T, Hisada T. Study of efficient homogenization algorithms for nonlinear problems. Computational Mechanics. 2010;46(2):247-58.

-Those published before 2010 are to be added.

(C) 2018 UT-Heart Inc.